Check out this post by Colleen Doran. No matter what your real estate agent or insurance broker might've told you, it's possible that your mortgage and/or insurance are null and void if you have a home office or just do business from your home. She says:
I sat down and REALLY read the fine print in my home loan agreement, and even though I had been told that my home office was OK and that my being an artist would not be a problem, the actual language of the loan specifically forbid my running any business from my home.
For any reason.
And at any time, if I had been called on it, I could have lost my home. The bank could have withdrawn the loan and foreclosed on my home because I was drawing comics in my home. No kidding. One neighbor with a grudge and a little smarts, and I could have lost my HOUSE.
Same with insurance. If your policy specifically forbids a home office, then if your place gets flooded out or burned down or quaked into a pile of rubble, you could be left with nothing if you do any work out of your house.
Check the fine print on your mortgage and insurance paperwork. I'm going to. :/